Symposium

12 Symposia

23-June (Tue) Day-2

Symposium 1-4: 13:30 – 16:00 (parallel) ; 3 invited talks & 2 short talks from abstracts

1

Mechanism for synthesis and action of seminal plasma, which will lead to develop the reproductive technology: (Tokachi Plaza)

Chair Masayuki Shimada (Japan)

Speakers and Titles

•John Schjenken (Australia)

“Exploring the influence of environmental exposures on seminal plasma composition”

John Schjenken is a senior lecturer and director of the Hunter Medical Research Institute Infertility and Reproduction Research Program (Infertility and Reproduction Research Program website) based at the University of Newcastle who teaches into the discipline of biological sciences program. His research program aims to advance knowledge of the male contribution at conception with emphasis on investigation the composition of seminal plasma and the function of signalling molecules present in this fluid. To achieve this, his group uses multi-omic approaches, combining transcriptomics, proteomics and bioinformatics.

•Sarah Robertson (Australia)

“Seminal fluid effects on female receptivity and pregnancy outcome”

Sarah Robertson, AO PhD FAA FAHMS is Professor of Reproductive Immunology and NHMRC Investigator Fellow in the Robinson Research Institute, University of Adelaide. Her research focus is the female immune response to seminal fluid, its significance for conception and pregnancy, and consequences for reproductive success and offspring health.

•Masayuki Shimada (Japan)

“Metabolic changes in seminal vesicle alter plasma components to enhance sperm fertility”

Masayuki Shimada, PhD, is Professor of Reproductive Biology in the Graduate School of Integrated Sciences for Life, Hiroshima University, Japan. His research has extended to basic research such as molecular reproductive endocrinology, sperm biology, and applied research such as the development of sperm preservation methods and sperm sexing technology.

2

Epigenetics in pathophysiology and disease: (Hotel Nikko Northland-A)

Chair Graça Ferreira Dias (Portugal)

Graça Ferreira-Dias, DVM, MSc, PhD, is a Full Professor in the Department of Morphology and Function at the Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal. Her most recent research focuses on the epigenetic in the equine endometrium, and their implications on the pathophysiology of fibrosis in endometrosis.

Speakers and Titles

•Hélène Kiefer (France)

“The bull sperm epigenome: Role in male fertility and transmission to the offspring”

Hélène Kiefer, PhD, is a researcher in the "Biology of Reproduction, Environment, Epigenetics and Development" research unit at INRAE, Jouy-en-Josas, France. Her research focuses on DNA methylation in cattle and its role in the elaboration of phenotypes. In particular, she is investigating the links between sperm DNA methylation and male fertility and offspring phenotype.

•Anna Szóstek-Mioduchowska (Poland)

“Exploring the role of epigenetic and miRNA in the processes related to the development of endometrosis in mare”

Anna Szóstek-Mioduchowska, PhD, is an Associate Professor, the Head of Team of Molecular Basis of Equine Reproduction in Institute of Animal Reproduction and Food Research, Polish Academy of Sciences in Olsztyn in Poland. Her research focuses on reproductive physiology in horses, particularly on molecular mechanisms regulating endometrial fibrosis.

•Bárbara Borges (Brazil)

“The role of epigenetic alterations in canine mammary cancer”

3

Environmental stressors and their impact on animal reproduction: (Hotel Nikko Northland-B)

Chair Zvi Roth (Israel)

Speakers and Titles

•Aileen F. Keating (USA)

“Effect of heat stress on reproduction in the pig”

•Peter J Hansen (USA)

“Genetic control of thermotolerance in cattle: implications for reproductive physiology”

•Zvi Roth (Israel)

“Effect of food borne toxins on the female and male gametes: the bovine model”

4

Latest advances in the controlled breeding of small ruminants: (Hotel Nikko Northland-C)

Chair Taylor Pini and Simon de Graaf (Australia) Simon de Graaf (Australia)

Simon de Graaf, PhD FRSN FSRB, is Professor of Animal Reproduction at The University of Sydney, Australia, Director of The Reproduction Company and Secretary General of ICAR. His research focuses on the controlled breeding of sheep, application of artificial intelligence to reproductive diagnostics, and the interaction between sperm, seminal plasma and the female reproductive tract. His commercial work centres on the independent analysis of livestock semen and the training of artificial breeding industry stakeholders in semen processing QA and QC.

Speakers and Titles

•Clara Gonzalez (USA)

“Sexed semen: current state-of-the-art in small ruminants”

Dr. Clara González-Marín holds a Ph.D. in Reproductive Physiology and Cellular Biology from Universidad Autónoma of Madrid and an M.S. in Reproductive Biology from Universidad Complutense of Madrid (Spain). She joined STgenetics in 2010 and currently leads the Research and Development in Male Reproduction, with a focus on sperm sex-sorting and reproductive biotechnologies. With over 15 years of experience in animal reproduction, Dr. González-Marín has led international research initiatives to improve sex-sorted sperm quality, fertility outcomes, and the efficiency of reproductive technologies across multiple species. She collaborates widely with global institutions to advance sustainable livestock production.

•Xavier Druart (France)

“Towards cervical AI of sheep with stored semen: latest insights and future developments”

•Jessica Rickard (Australia)

“Maximising the success of laparoscopic artificial insemination in small ruminants”

Dr Jessica Rickard, PhD is a Senior lecturer in Livestock Production and Reproduction within the School of Life and Environmental Sciences, Faculty of Science at The University of Sydney, Australia. Her research focuses on understanding the interaction between seminal plasma, spermatozoa and the female reproductive tract, to improve the success of artificial reproductive technologies with cryopreserved sperm in sheep. She is also working to adapt these techniques for use in wildlife conservation programs.

“Tasting Hokkaido foods, wine and beer !” (Tokachi Plaza Garden) 18:30 – 21:00

24-June (Wed) Day-3

Free for the afternoon (Excursions & Activities)

25-June (Thu) Day-4

Symposium 5-8: 13:30 – 16:00 (parallel); 3 invited talks & 2 short talks from abstracts

5

Bull fertility: paternal factors regulating pregnancy establishment in cattle: (Tokachi Plaza)

Chair Sean Fair (Ireland) and Giuliana Ferronato (Spain)

Speakers and Titles

•Sean Fair (Ireland)

“Sperm in the uterus: The role of sperm subpopulations in regulating fertility”

Sean Fair is Professor of Animal Reproduction and Head of the Department of Biological Sciences at the University of Limerick, Ireland. His research group uses physiological and molecular approaches to study the complex and multidimensional etiology of subfertility in farm animals with a specific focus on how sperm interact with the female reproductive tract and its secretions using both in vivo and in vitro models.

•Akio Miyamoto (Japan)

“Innate immune system for a crosstalk of sperm-egg-uterine epithelium toward successful pregnancy”

Akio is a professor of Global Agromedicine Research Center (GAMRC) of Obihiro University of Agriculture and Veterinary Medicine, Japan. He is currently interested in the immune-crosstalk of sperm and embryos with uterine and oviduct. His team recently found that the innate immune receptor, TLR2, is involved in such a communication for proceeding on the path to fertilization and embryo receptivity in the cow. Akio is a true beer lover, those from Munich, Ireland, Japan and many other countries !

•Sofia Ortega (USA)

“Paternal effects on preimplantation development and placentation in the bovine”

Dr. M. Sofia Ortega is an Assistant Professor in the Department of Animal and Dairy Sciences at the University of Wisconsin-Madison, USA; her program studies the genetic, molecular, and physiological factors that influence early embryonic development and pregnancy in dairy cattle.

6

From egg to newborn, pathways to healthy canine pregnancy: (Hotel Nikko Northland-A)

Chair Mariusz Kowalewski (Switzerland)

Speakers and Titles

•Nucharin Songsasenn (USA)

“Development and maturation of canine oocytes: Roles of ovarian and oviductal environment in the acquisition of meiotic competence”

Nucharin Songsasen, DVM, PhD is the Head of the Center for Species Survival, Smithsonian's National Zoological Park and Conservation Biology Institute. Her research focus on understanding reproductive biology and developing reproductive technologies in domestic and wild carnivores.

•Mariusz Kowalewski (Switzerland)

“Understanding canine pregnancy: New insights into morphofunctional dynamics during establishment and maintenance”

Mariusz P. Kowalewski, PhD, is a Professor of Veterinary Anatomy, Histology, and Embryology, and Head of the Institute of Veterinary Anatomy at the Vetsuisse Faculty, University of Zurich, Switzerland. His research group of Reproductive Endocrinology investigates endocrine regulations of canine placental and luteal function, conceptus-maternal communication and canine-specific mechanisms of decidualization, and the mechanisms of hypoxia and HIF1α-mediated steroidogenesis.

•Orsolya Balogh (USA)

“When physiology fails: Endocrine and clinical perspectives on complicated pregnancy outcomes in dogs”

Orsolya Balogh, DVM, PhD, DACT is an Associate Professor and the JoAnne S. O’Brien Endowed Professor of Theriogenology in the Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, USA. Her research centers around the physiology of pregnancy and parturition in dogs, focusing on maternal obesity and the molecular aspects of uterine inertia.

7

Neural and hormonal regulation of reproduction: From basic research to application in animal production:(Hotel Nikko Northland-B)

Chair Satoshi Ohkura (Japan)

Speakers and Titles

•Satoshi Ohkura (Japan)

“Neuroendocrine mechanisms leading to novel control techniques of reproduction in livestock”

Satoshi Ohkura, Ph.D., is a Professor at the Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan. His current research focuses on the neuroendocrine mechanism underlying the regulation of the pulsatile release of gonadotropin-releasing hormone (GnRH) in ruminant species, especially in goats.

•Casey Nestor (USA)

“Neuronal networks function to link reproduction and energy homeostasis in farm animals”

Casey Nestor, PhD, is an Associate Professor in the Department of Biomedical Sciences at Colorado State University in Fort Collins Colorado USA. His research examines central mechanisms whereby undernutrition suppresses the reproductive axis using sheep as a neuroendocrine model. His laboratory team routinely employs neuroanatomical approaches such as RNAscope and immunohistochemistry together with central drug delivery and frequent blood collection to assess the role of various components that regulate GnRH/LH secretion.

•Agnieszka Rak (Poland)

“Adipokines as a new regulator of the hypothalamus-pituitary-ovary axis in domestic animals”

Agnieszka Rak, PhD, is a Professor in the Laboratory of Physiology and Toxicology of Reproduction in Institute of Zoology and Biomedical Research at the Faculty of Biology, Jagiellonian University in Kraków, Poland. Her research centers on molecular regulation of female reproduction at hypothalamus - pituitary - ovary levels in mammals, with a particular focus on role of adipokines.

8

Effects of environmental toxins on follicle function: (Hotel Nikko Northland-C)

Chair Christopher Price (Canada)

Christopher Price, PhD, is a Professor in the Faculty of Veterinary Medicine at the University of Montreal, Québec, Canada. His research focuses on ovarian physiology, with a keen interest in environmental and endocrine modulators of follicle development in dairy cattle.

Speakers and Titles

•Vasantha Padmanabhan (USA)

“Living in a Chemical Cocktail: Real-World Exposures and Their Impact on Ovarian Function”

Vasantha Padmanabhan, MS, PhD, is Professor Emerita (in service) in the Department of Pediatrics, University of MIchigan, USA. Her research centers on developmental origin of reproductive and metabolic dysfunctions. She uses sheep as a model system to study the impact of inappropriate gestational exposure to steroids and real-life environmental chemical mixtures on offspring reproductive and metabolic health.

•Shuo Xiao (USA)

“Ovarian disrupting effects of harmful algal bloom toxins”

•Sebastien Elis (France)

“Bisphenols and follicle function in farm species”

Sebastien Elis defended his PhD in 2007 on oocyte competence in hens at INRAE, France. He then worked as a postdoctoral fellow at the Mount Sinai School of Medicine in New York, USA, in the field of endocrinology, investigating the effects of tissue-derived versus systemic IGF-1 on bone growth. In 2009, he was recruited by INRAE, where he studied the interactions between metabolism and reproduction in ruminants. He is now particularly involved in research on the effects of endocrine disruptors on female fertility and ovarian function.

26-June (Fri) Day-5

Symposium 9-12: 13:30 – 16:00 (parallel) ; 3 invited talks & 2 short talks from abstracts

9

Ungulate placentation: update on old and new approaches and models: (Tokachi Plaza)

Chair Christiane Pfarrer (Germany)

Speakers and Titles

•Kshitiz (USA)

“What controls placental invasion?”

Kshitiz is an Associate Professor at the University of Connecticut Health, USA, and Director of the Evolutionary Medicine Laboratory. Kshitiz earned his B.Tech. In Computer Science at the Indian Institute of Technology, Bombay, and his PhD in Biomedical Engineering at the Johns Hopkins Medicine under supervision of Dr. Andre Levchenko and Dr. Gregg Semenza. He then started a startup in Seattle, before returning back to academia as a Research Associate at Yale University, where he stumbled upon the confluence of cancer and evolutionary biology with Gunter Wagner. Kshitiz joined UConn Health in 2018, and has developed a new research program in evolutionary medicine, along with multiple startups in cancer therapy, AI, and reproductive biology. Along with this, Kshitiz is a classical dancer, and an author of books centered on ancient classics.

•Toshihiro Sakurai (Japan)

“Update on endogenous retroviruses in cattle placenta”

Toshihiro Sakurai, Ph.D., is a Professor at the School of Pharmaceutical Sciences, Ohu University, Japan. His research focuses on the molecular regulatory mechanisms of placental development in cattle, with particular emphasis on the roles of endogenous retroviruses.

•Christiane Pfarrer (Germany)

“3-D imaging of the fetomaternal placentomal contact interface”

Dr. med. vet. Christiane Pfarrer is Full Professor and Head of the Institute for Anatomy at the University of Veterinary Medicine Hannover, Germany. Her research is focussed on comparative placentation, with special respect to the development of in vitro models for the bovine placenta and analysis of the fetomaternal contact interface by molecular biological and histological methods (from light microscopy to electron microscopy, including 3-D reconstruction).

•Thomas Spencer (USA)

“Deconstructing bovine placentation: insights from in vivo single cell analyses and in vitro culture”

10

Manipulation of germ cells: Toward efficient production of food animals: (Hotel Nikko Northland-A)

Chair Goro Yoshizaki (Japan)

Speakers and Titles

•Goro Yoshizaki (Japan)

“Germ cell manipulation in farmed fishes”

Goro Yoshizaki, PhD, is a Professor in the Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Japan. His research centers on germ-cell manipulation in fish, with a particular focus on its applications to aquaculture and fish conservation.

•Mike McGrew (United Kingdom)

“Manipulating reproductive germ cells from poultry and other bird species”

•Ina Dobrinski (Canada)

“Male germ cell manipulation in large animals ”

Ina Dobrinski, Dr.med.vet., MVSc, PhD, Dip. ACT, is Professor for Reproductive Biology in the Department of Biochemistry & Molecular Biology in the Cumming School of Medicine, and the Faculty of Veterinary Medicine, University of Calgary, Canada. Her research centers on male germline stem cells, with a focus on large animal models and transplantation.

11

Promising directions for pig reproduction research: (Hotel Nikko Northland-B)

Chair Pascal Mermillod (France)

Speakers and Titles

•Marc Yeste (USA)

“Perspectives in porcine semen conservation (liquid and frozen)”

•Marie Saint Dizier (France)

“Sperm-female interactions in the pig oviduct: A key for insemination success?”

Marie Saint-Dizier, DVM, PhD, is a Professor at the University of Tours, France, and at the French National Institute for Agriculture, Food and Environment (INRAE). Her research centers on maternal interactions with gametes and embryos during the periconception period, with a particular focus on the oviduct epithelium and its impact on sperm selection and embryo quality.

•Cristina Cuello (Spain)

“Promising research directions for pig embryo production, freezing and transfer”

Cristina Cuello, DVM, PhD, is a Full Professor in the Department of Animal Medicine and Surgery at the University of Murcia, Spain. A member of the Animal Reproduction research group, her work focuses on embryonic technologies in pigs, with emphasis on in vitro embryo production, embryo cryopreservation and transfer, and, more recently, genome editing of porcine embryos using CRISPR.

12

Buffalo reproduction: (Hotel Nikko Northland-C)

Chair Bianca Gasparini (Italy) and Pietro Baruselli (Brazil)

Speakers and Titles

•Aixin Liang (China)

“Genetics and reproduction in buffalo”

Aixin Liang, PhD, is an associate professor in the College of Animal Science and Technology at Huazhong Agricultural University, China. Her research focuses on animal reproductive physiology and biotechnology, with a particular emphasis on reproductive regulation in buffaloes.

•Bianca Gasparini (Italy)

“Factors affecting buffalo oocyte competence and embryo production”

Bianca Gasparrini, DVM, PhD, is Full Professor in the Department of Veterinary Medicine and Animal Production, Federico II University of Naples, Italy. Her research focuses on advanced reproductive technologies in livestock, with a specific emphasis on in vitro embryo production in buffalo and cattle, and on factors affecting oocyte developmental competence

•Naresh Selokar (India)

“New reproductive biotechnologies in buffaloe”

Naresh Selokar, B.V.Sc., Ph.D., is a Senior Scientist in the Department of Animal Biotechnology at ICAR–National Dairy Research Institute, Karnal, India. His research focuses on reproductive biotechnologies, with a special emphasis on animal cloning and genome editing in buffalo and cattle.

Gala Dinner (Hokkaido Hotel) 19:00 – 21:30